Since the early days of modern genetics, researchers have largelyshut their ears to the "background noise" of genetic modifiersthat modulate the expression of mendelian traits. Because modifiergenes complicate regular patterns of inheritance and becausetheir identification can be difficult, their importance hasbeen recognized, but they have rarely been the focus of geneticstudies. However, attention is beginning to focus on these geneticbackground effects, in part because they are the entréeinto the genetics and systems biology of more complex and commondiseases, and in part because they have great potential as powerfuland effective ways . . . [Full Text of this Article]
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From the Department of Genetics and the Center for Computational Genomics and Systems Biology, Case Western Reserve University School of Medicine, Cleveland.
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