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Previous Volume 352:1598-1599 April 14, 2005 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Since the early days of modern genetics, researchers have largely shut their ears to the "background noise" of genetic modifiers that modulate the expression of mendelian traits. Because modifier genes complicate regular patterns of inheritance and because their identification can be difficult, their importance has been recognized, but they have rarely been the focus of genetic studies. However, attention is beginning to focus on these genetic background effects, in part because they are the entrée into the genetics and systems biology of more complex and common diseases, and in part because they have great potential as powerful and effective ways . . . [Full Text of this Article]

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From the Department of Genetics and the Center for Computational Genomics and Systems Biology, Case Western Reserve University School of Medicine, Cleveland.

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