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Clinical Implications of Basic Research
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Volume 352:1600-1602 April 14, 2005 Number 15
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Arrest in the Liver — A Genetically Defined Malaria Vaccine?
Ute Frevert, D.V.M., Ph.D., and Elizabeth Nardin, Ph.D.

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Malaria is a disease with far-reaching effects: 40 percent of the world's population is at risk for malarial infection, approximately 300 million to 400 million cases occur annually, and each year, 1 million to 2 million people — predominantly young children — die of malaria. And yet there are no vaccines for parasitic diseases that affect humans, let alone a vaccine for malaria.

Sporozoites, the infectious stage of the malaria parasite plasmodium, are small, slender, unicellular organisms that mature in the salivary glands of anopheline mosquitoes. Exposure to radiation-attenuated sporozoites, however, can elicit a cell- and antibody-mediated immune response sufficient . . . [Full Text of this Article]


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From the Department of Medical and Molecular Parasitology, New York University School of Medicine, New York.



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