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Previous Volume 352:1605-1607 April 14, 2005 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Paik et al. (Dec. 30 issue)¹ imply that their multigene assay provides more objective and reproducible information than an assigned tumor grade. Any RNA-based gene-expression profile of neoplasms is heavily dependent on tumor cellularity. Moreover, different areas of the tumor may be expected to show different gene-expression patterns. Therefore, selection of the area to be measured becomes a critical issue. Many breast-cancer specimens may be represented in two or more paraffin blocks, and it is unknown how the recurrence score in the current study would have been affected by the choice of block. The authors studied within-patient . . . [Full Text of this Article]

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