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Volume 352:1608-1610 April 14, 2005 Number 15
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Prophylaxis against Rabies

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 by Rupprecht, C. E.
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To the Editor: As noted by Rupprecht and Gibbons (Dec. 16 issue),1 delay before postexposure prophylaxis against rabies is initiated may result in treatment failure and death.2 The incubation period for rabies in dogs could be much longer than 10 days. Furthermore, in previous studies, the rabies virus was isolated from the saliva and cerebrospinal fluid of many dogs before they had any signs of rabies,3 and up to 18 percent of the infected dogs died without having shown any signs of illness beforehand.4 Therefore, management by 10-day observation in many areas where rabies is still prevalent might put patients' . . . [Full Text of this Article]




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