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Previous Volume 352:1741-1744 April 28, 2005 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The number of newly identified genes participating in the regulation of iron homeostasis has increased at a remarkable pace. The characterization of these genes has led investigators to challenge previous models of the regulation of iron homeostasis in health and its dysregulation in disease. There is now substantial evidence that the liver plays a central role in determining how much iron is absorbed from the gut and in influencing the release of iron from sites of storage. The discovery of the iron regulatory hormone hepcidin has provided a cohesive theory to explain the pathophysiology of such common disorders as hereditary . . . [Full Text of this Article]

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Dr. Fleming is an associate professor of pediatrics and biochemistry and molecular biology and Dr. Bacon a professor of internal medicine at the Saint Louis University School of Medicine, St. Louis.

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