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Previous Volume 352:1820-1822 April 28, 2005 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We believe Meyerhardt and Mayer's discussion of regional, targeted therapies for colorectal cancer (Feb. 3 issue)¹ is incomplete. Regional infusion of interleukin-2 or interferon alfa through the hepatic artery, combined with chemotherapy, yields better results than chemotherapy alone in patients with metastatic colorectal disease.^2,3,4 Moreover, modulation of fluorouracil-metabolizing enzymes by interleukin-2 appears to enhance the effectiveness of this chemotherapeutic agent. In addition, major surgery for liver metastases induces stimulation of angiogenesis and immunosuppression consisting of lymphocytopenia, reductions in the blood levels of antitumor interleukin-2 and interleukin-12, and increases in the level of immunosuppressive interleukin-6.⁵ On the other . . . [Full Text of this Article]

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