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Previous Volume 352:1822-1824 April 28, 2005 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In regard to the review of insulin analogues by Hirsch (Jan. 13 issue),¹ recurrent hypoglycemia is a major impediment to the achievement of good metabolic control, as defined by the Diabetes Control and Complications Trial.² Furthermore, asymptomatic nocturnal hypoglycemic episodes are important because they reduce counterregulation and thereby increase the risk of subsequent prolonged and severe hypoglycemia, associated occasionally with coma.³ This is particularly true for small children, who have been shown to sleep through episodes of prolonged hypoglycemia. The use of regular insulin before the evening meal leads to overinsulinization during the early part of the . . . [Full Text of this Article]

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