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Previous Volume 352:2020-2021 May 12, 2005 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Metastasis, the leading cause of death in patients with cancer, is a sequential process that allows cells to move from the primary tumor and grow elsewhere. The development of the metastatic program requires the establishment of a vibrant communication network between tumor cells and nontransformed cells in the host. A recent report by Boire et al.¹ underscores this concept; it shows that matrix metalloproteases (MMPs) secreted by host fibroblasts promote tumor-cell invasion by activating a G-protein–coupled receptor — the protease-activated receptor 1 (PAR1). This work adds to the growing catalogue of highly specific roles played by MMPs during tumor invasion . . . [Full Text of this Article]

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From the Medical Oncology Research Program, Vall d'Hebron University Hospital Research Institute, Barcelona.

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