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Volume 352:2027-2028 May 12, 2005 Number 19
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Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection

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by Dragun, D.
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To the Editor: Dragun et al. (Feb. 10 issue)1 provide provocative data on the role of agonistic angiotensin II type 1 (AT1)–receptor antibodies in patients with steroid-refractory renal-allograft rejection. We were surprised by the high incidence of biopsy-proved acute rejection among their patients (43 percent), which contrasts with the 15 percent previously reported with a similar immunosuppressive protocol.2,3 In addition, 16 of the 33 patients with steroid-refractory rejection in the study by Dragun et al. appeared to have malignant hypertension. The median blood pressure was 153/80 mm Hg in the 10 most recent patients with steroid-refractory rejection in our . . . [Full Text of this Article]



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