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Previous Volume 352:174-183 January 13, 2005 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The discovery of insulin more than 80 years ago is considered one of the greatest medical breakthroughs of the 20th century.¹ The first commercial insulin preparations contained numerous impurities and varied in potency from lot to lot by as much as 25 percent. Manufacturing techniques improved rapidly, however, which allowed the production of higher-quality formulations from bovine and porcine sources. In the 1930s, the first long-acting preparation, protamine zinc insulin, was developed to reduce the number of injections necessary for adequate insulin replacement.² This preparation was often used once daily, without the addition of regular insulin, which set a trend . . . [Full Text of this Article]

Rapidly Acting Analogues

Pharmacokinetic and Pharmacodynamic Issues

Clinical Effectiveness

            Type 1 Diabetes

            Type 2 Diabetes

Hypoglycemia

Practical Issues

Premixed Insulins

Self-Monitoring of Blood Glucose

Long-Acting Analogues

Pharmacokinetic and Pharmacodynamic Issues

Clinical Effectiveness

            Type 1 Diabetes

            Type 2 Diabetes

Special Populations

Children

Pregnant Women

Continuous Subcutaneous Insulin Infusion

New Analogues

Conclusions

Source Information

From the Department of Medicine, University of Washington School of Medicine, Seattle.

Address reprint requests to Dr. Hirsch at the Department of Medicine, University of Washington School of Medicine, 1959 N.E. Pacific St., Box 356176, Seattle, WA 98195-6176, or at ihirsch@u.washington.edu.

Related Letters:

Insulin Analogues
Mohn A., Marcovecchio M., Chiarelli F., Haffner M. C., Kufner M. P., Boehm B. O., Hirsch I. B.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:1822-1824, Apr 28, 2005. Correspondence

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