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Volume 352:2140-2141 May 19, 2005 Number 20
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The Unturned Stone

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 by Goulet, C. J.
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To the Editor: AIDS is a well-known predisposing condition for generalized histoplasmosis, which had been ruled out in the patient described in the Clinical Problem-Solving article by Goulet et al. (Feb. 3 issue).1 Idiopathic CD4+ lymphocytopenia2 is another immunodeficiency state that should be ruled out in such a case. I would like to know what the absolute lymphocyte count and CD4+ count were in this patient. In idiopathic CD4+ lymphocytopenia, several other opportunistic infections, such as cryptococcal meningitis, toxoplasmosis, Pneumocystis carinii pneumonia,3 and disseminated warts, have been described. In general, patients with idiopathic CD4+ lymphocytopenia have stable CD4+ cell counts. . . . [Full Text of this Article]




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