Older people and their physicians are all too well acquaintedwith herpes zoster commonly called shingles, from theLatin cingulum, or "girdle." Most recognize that aging createsa special vulnerability to this often severely painful skinrash caused by varicellazoster virus (VZV). VZV is sonamed because varicella (chickenpox) represents the first encounterbetween the virus and the host, and herpes zoster representsthe second. VZV persists in the sensory ganglia of the cranialnerves and the spinal dorsal-root ganglia after varicella resolves,and it may become reactivated after many decades of latency;molecular analyses of VZV DNA demonstrate . . . [Full Text of this Article]
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Dr. Arvin is a professor of pediatrics and microbiology and immunology at the Stanford University School of Medicine, Stanford, Calif.
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