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Previous Volume 352:2268-2270 June 2, 2005 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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All of us carry millions of variations in the sequences of our genomes and thousands of mutations in genes, some of which alter the amino acid sequences of proteins. The majority of the variations in genomes and even many of the changes in the sequences of proteins have no apparent effect on the risk of death or on longevity. The challenge of current molecular genetics is to distinguish the neutral variations from mutations that alter the functions of proteins sufficiently to predispose us to disease.

In their study reported in this issue of the Journal, Liu et al. (pages 2294–2301) . . . [Full Text of this Article]

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Dr. Prockop is the director of the Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans.

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