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Volume 352:2350-2353 June 2, 2005 Number 22
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Treatment of Brain Tumors

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To the Editor: In the report by Rutkowski et al. (March 10 issue)1 regarding treatment of early childhood medulloblastoma with postoperative chemotherapy alone, 20 of 43 children under the age of three years (46.5 percent) had desmoplastic medulloblastoma, and these 20 children had a five-year progression-free survival rate of 85 percent. The desmoplastic variant is considered to be less aggressive than classic medulloblastoma and occurs mainly in adolescents and adults.2,3 As far as we know, desmoplastic histologic features are not found in a large proportion of children who are younger than three years of age. Could the somewhat higher-than-expected proportion . . . [Full Text of this Article]


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