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Previous Volume 352:2446-2448 June 9, 2005 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Pioneering work on the nematode Caenorhabditis elegans has yielded a wealth of insight into signaling pathways, revealing regulatory mechanisms that are critical to both developmental biology and tumorigenesis. For example, studies of vulval development in the worm were instrumental in identifying components of RAS–mitogen-activated protein kinase signaling. These are highly conserved across species and regulate the growth of normal and malignant cells in mammals. The study of C. elegans facilitated another important discovery: the existence of noncoding microRNAs. These tiny fragments of RNA (about 22 nucleotides long) regulate gene expression by hybridizing to complementary sequences in the 3' untranslated region . . . [Full Text of this Article]

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From the Department of Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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