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Volume 352:2454-2456 June 9, 2005 Number 23
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The Serotonin Syndrome

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by Boyer, E. W.
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To the Editor: The review of the serotonin syndrome by Boyer and Shannon (March 17 issue)1 raises some questions. First, how many features make a diagnosis of the serotonin syndrome? This is especially relevant when a patient presents with nonspecific symptoms (agitation, tachycardia, tremor, diarrhea, or a combination) that are often early and transient side effects of selective serotonin-reuptake inhibitors (SSRIs). An overenthusiastic diagnosis of the serotonin syndrome at this stage may actually deprive the patient of the benefits of SSRI treatment for depression.

Second, SSRIs and other proserotonergic agents act, by definition, by raising serotonergic activity in the brain. . . . [Full Text of this Article]



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