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Volume 352:2456-2457 June 9, 2005 Number 23
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Acute Doxorubicin Cardiotoxicity

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To the Editor: A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin level was markedly elevated (2233 ng per milliliter; normal, <180), as was urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) (118.7 mg per 24 hours; normal, <6.0), and a computed tomographic (CT) scan revealed a small-bowel mass, 3 cm by 2.5 cm, with multiple hepatic lesions. Fine-needle liver biopsy demonstrated cytokeratin- and chromogranin-staining cells, which are characteristic of carcinoid tumor. Despite monthly injections of octreotide, the patient's flushing persisted, and a CT scan showed enlargement of both small-bowel and liver masses. She . . . [Full Text of this Article]


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