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A five-year-old girl received the diagnosis of respiratory papillomatosis after an episode of respiratory distress in which the collapse of the right lung required intubation. During bronchoscopy, a single laryngeal papilloma and multiple tracheal papillomas (Panel A) were seen (up to a distance of 1.5 cm above the carina), which partially obstructed the lumen of the airway. In situ hybridization of the pathological specimen with a probe for human papillomavirus serotypes 6 and 11 confirmed that it contained the virus. The patient was treated with interferon and with periodic laser removal of the recurrent laryngotracheal papillomas. Sixteen months later, pulmonary . . . [Full Text of this Article] |