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Previous Volume 352:2576-2578 June 23, 2005 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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On November 23, 2000, the results of the Vioxx Gastrointestinal Outcomes Research study, known as VIGOR, were published in the Journal. This randomized, controlled trial showed that rofecoxib, an inhibitor of cyclooxygenase-2 that had been marketed as Vioxx since May 1999, was associated with fewer gastrointestinal complications than naproxen, a standard nonsteroidal antiinflammatory drug. Unexpectedly, the VIGOR study also showed that the patients who were given rofecoxib had four times as many myocardial infarctions as those who were given naproxen.

This finding of a significant increase in the risk of myocardial infarction was an early signal of a potentially . . . [Full Text of this Article]

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Mr. Waxman is a U.S. Representative from California.

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The Lessons of Vioxx
Frazier K. C., Waxman H. A.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:1420-1421, Sep 29, 2005. Correspondence

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