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Clinical Implications of Basic Research
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Volume 352:2645-2646 June 23, 2005 Number 25
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How Ebola Virus Infects Cells
Yoshihiro Kawaoka, D.V.M., Ph.D.

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Despite its isolation three decades ago, Ebola virus continues to cause periodic outbreaks of severe hemorrhagic fever in humans, and the closely related Marburg virus is responsible for a recent outbreak of disease in Angola. The mortality rate associated with Ebola virus infection can reach 90 percent, and so the prospect of an effective therapy is attractive. A recent study by Chandran et al.1 sheds light on the molecular events that culminate in infection and may thus lead to a new approach to therapy.

Embedded within the host-derived lipid envelope of Ebola virus are glycoprotein spikes that bind to cells . . . [Full Text of this Article]


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From the International Research Center for Infectious Diseases and the Division of Virology, the Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo; and the Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, Madison.




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