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Previous Volume 352:2752-2753 June 30, 2005 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Bertram et al. (March 3 issue)¹ report that in two family-based cohorts, a genetic variant of the UBQ-8i single-nucleotide polymorphism on chromosome 9q22 putatively increased the risk of Alzheimer's disease in an additive disease model. We attempted replication in a similarly ascertained but independent family-based data set based on 288 families in which linkage to microsatellites at 9q22.1 and 9q34.2 was demonstrated in a genome scan.² In addition, we analyzed a previously described independent data set based on patients with Alzheimer's disease and 1005 controls.³

We found no association between the risk of Alzheimer's disease and UBQ-8i, . . . [Full Text of this Article]

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