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Clinical Implications of Basic Research
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Volume 352:298-300 January 20, 2005 Number 3
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Topical Microbicides Become Topical
John P. Moore, Ph.D.

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Developing a preventive human immunodeficiency virus type 1 (HIV-1) vaccine that decisively reduces the rate of spread of the AIDS pandemic will take many years, at best. In the meantime, can the scientific community apply other biology-based methods to halt the transmission of HIV-1? A recent study performed by Lederman and colleagues with the use of a nonhuman primate model of sexual transmission indicates that this feat may be possible.1 By applying a specific inhibitor of virus–cell fusion to the vaginal vault of rhesus macaques, Lederman et al. protected the animals against a subsequent challenge by a vaginally inoculated, genetically . . . [Full Text of this Article]


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From the Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York.


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