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A correction has been published: N Engl J Med 2005;352(11):1163.

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Volume 352:301-304 January 20, 2005 Number 3
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Oral Erythromycin and the Risk of Sudden Death

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 by Liu, B. A.
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 by Ray, W. A.
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To the Editor: Ray and colleagues (Sept. 9 issue)1 seem to have overlooked several important issues when describing the association of erythromycin with the risk of sudden death from cardiac causes. First, was there a higher risk associated with any specific erythromycin preparations? The most recent edition of The Use of Antibiotics, edited by Kucers et al., lists six available erythromycin preparations (base, stearate, estolate, ethylsuccinate, ascitrate, and parenteral erythromycin).2 Can the authors differentiate the risks associated with these preparations?

Second, the authors mention clarithromycin as "a strong CYP3A inhibitor," yet they consider this antibiotic separately and do not offer . . . [Full Text of this Article]




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