Wegener's syndrome (Wegener's granulomatosis) is a rare systemicdisorder, and because it involves multiple organs, affectedpatients may seek help from physicians in many specialties.It is classified as a type of primary systemic vasculitis, andthe typical renal glomerular involvement is histologically identicalto that seen in microscopic polyangiitis. However, Wegener'ssyndrome also involves multiple other organs. The clinical pictureincludes airway disease and skin, eye, and joint involvement,which therefore figure in the diagnostic criteria. Unlike microscopicpolyangiitis, the lesions in Wegener's syndrome are largelygranulomatous. Vasculitis and granulomata can occur in the samelesion, but they commonly . . . [Full Text of this Article]
Source Information
Dr. Bacon is a professor of rheumatology at the University of Birmingham, Birmingham, United Kingdom.
This article has been cited by other articles:
Gomez-Puerta, J. A., Bosch, X.
(2009). Anti-Neutrophil Cytoplasmic Antibody Pathogenesis in Small-Vessel Vasculitis: An Update. Am. J. Pathol.
175: 1790-1798
[Abstract][Full Text]
Gomez-Puerta, J. A., Hernandez-Rodriguez, J., Lopez-Soto, A., Bosch, X.
(2009). Antineutrophil Cytoplasmic Antibody-Associated Vasculitides and Respiratory Disease. Chest
136: 1101-1111
[Abstract][Full Text]
Ullrich, S, Gustke, H, Lamprecht, P, Gross, W L, Schumacher, U, Ambrosch, P, Laudien, M
(2009). Severe impaired respiratory ciliary function in Wegener granulomatosis. Ann Rheum Dis
68: 1067-1071
[Abstract][Full Text]
Lamprecht, P., Gross, W. L.
(2008). A little help from our friends: what an epidemiologic study teaches us about autoinflammation, granuloma and proteinase-3-specific antineutrophil cytoplasmic autoantibodies. Nephrol Dial Transplant
23: 3743-3745
[Full Text]
Mukhtyar, C, Flossmann, O, Hellmich, B, Bacon, P, Cid, M, Cohen-Tervaert, J W, Gross, W L, Guillevin, L, Jayne, D, Mahr, A, Merkel, P A, Raspe, H, Scott, D, Witter, J, Yazici, H, Luqmani, R A, on behalf of the European Vasculitis Study Group (,
(2008). Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force. Ann Rheum Dis
67: 1004-1010
[Abstract][Full Text]
Jayne, D.
(2007). Leflunomide versus methotrexate in Wegener's granulomatosis. Rheumatology (Oxford)
46: 1047-1048
[Full Text]
Stewart, C., Cohen, D., Bhattacharyya, I., Scheitler, L., Riley, S., Calamia, K., Migliorati, C., Baughman, R., Langford, P., Katz, J.
(2007). Oral manifestations of Wegener's granulomatosis: A report of three cases and a literature review. Journal of the American Dental Association
138: 338-348
[Abstract][Full Text]
Voswinkel, J, Mueller, A, Kraemer, J A, Lamprecht, P, Herlyn, K, Holl-Ulrich, K, Feller, A C, Pitann, S, Gause, A, Gross, W L
(2006). B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions. Ann Rheum Dis
65: 859-864
[Abstract][Full Text]
Pusey, C. D.
(2006). The Continuing Challenge of Anti-Neutrophil Cytoplasm Antibody-Associated Systemic Vasculitis and Glomerulonephritis. J. Am. Soc. Nephrol.
17: 1221-1223
[Full Text]
Aries, P. M., Lamprecht, P., Gross, W. L.
(2006). Rituximab in refractory Wegener's granulomatosis: favorable or not?. Am. J. Respir. Crit. Care Med.
173: 815a-8816
[Full Text]
Hogan, S. L., Falk, R. J., Chin, H., Cai, J., Jennette, C. E., Jennette, J. C., Nachman, P. H.
(2005). Predictors of Relapse and Treatment Resistance in Antineutrophil Cytoplasmic Antibody-Associated Small-Vessel Vasculitis. ANN INTERN MED
143: 621-631
[Abstract][Full Text]
Mukhtyar, C, Luqmani, R
(2005). Current state of tumour necrosis factor {alpha} blockade in Wegener's granulomatosis. Ann Rheum Dis
64: iv31-iv36
[Abstract][Full Text]