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Volume 352:418-419 January 27, 2005 Number 4
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Pulmonary Hypertension

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by Farber, H. W.
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To the Editor: In their review of pulmonary hypertension, Farber and Loscalzo (Oct. 14 issue)1 suggest that chronic hypoxia causes pulmonary hypertension by producing structural changes in the vasculature. This widely accepted view postulates two major changes: thickening of the arteriolar wall with encroachment into the vessel lumen and a loss of blood vessels; more recent evidence calls this view into question. By applying quantitative stereologic techniques to this problem, we showed that hypoxia-induced vascular-wall remodeling did not reduce the maximal luminal diameter.2 Furthermore, we found that chronic hypoxia stimulated angiogenesis in the pulmonary circulation, not loss of vessels.2 More . . . [Full Text of this Article]



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