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Previous Volume 352:506-508 February 3, 2005 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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G protein–coupled receptors represent the largest superfamily of receptors in the human genome. They are intricate sensors and transducers and are fundamental to physiology and disease. Drugs that target these receptors have therapeutic utility and potential and include beta-blockers and blockers of type 1 angiotensin (AT₁) receptors. Traditionally, G protein–coupled receptors were thought to act as monomers, in which one ligand binds and activates a single receptor–G protein complex. Newer evidence,¹ however, points to the existence of higher-order complexes (dimers or oligomers) with altered pharmacology, responsiveness, or both.^2,3 A recent report by AbdAlla and colleagues⁴ not only underscores the . . . [Full Text of this Article]

Source Information

From the Baker Heart Research Institute, Melbourne, Australia.

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