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Volume 352:835-836 February 24, 2005 Number 8
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Telmisartan vs. Enalapril in Type 2 Diabetes

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 by Barnett, A. H.
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To the Editor: Barnett et al. (Nov. 4 issue)1 compared telmisartan and enalapril in type 2 diabetic nephropathy, without reporting or adjusting for certain major risk factors associated with diabetic nephropathy: glycemic control and hyperlipidemia. They assessed blood-pressure changes as a secondary end point, but their results indicate important issues regarding the extent to which their study can be generalized.

It is not clear why the target blood pressure was initially less than 160/90 mm Hg and what the subsequent, lower targets were during the study. The currently recommended blood-pressure goal for antihypertensive therapy in patients with diabetic nephropathy is . . . [Full Text of this Article]


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