The choice of delaying pregnancy has become the norm for manywomen in developed countries. Among some women, however, achievingpregnancy may be difficult or impossible at a later time. Theability to preserve fertility with various methods has becomea key issue for some women. Although the need is most pressingamong women with cancer, the same therapeutic options may beavailable for many other women who are reaching an advancedreproductive age. However, in this group, the use of the availabletechniques is controversial and should be considered experimental.
Defining the Population at Risk for Reproductive Failure
Testing for Decreased Ovarian Reserve
Options for Preserving Fertility
Conclusions
Source Information
From the Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons and New YorkPresbyterian Hospital, New York.
Address reprint requests to Dr. Lobo at the Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons and New YorkPresbyterian Hospital, 622 W. 168th St., New York, NY 10032, or at ral35@columbia.edu.
Maman, E., Prokopis, K., Levron, J., Carmely, A., Dor, J., Meirow, D.
(2008). Does controlled ovarian stimulation prior to chemotherapy increase primordial follicle loss and diminish ovarian reserve? An animal study. Hum Reprod
0: den337v1-4
[Abstract][Full Text]
Blumenfeld, Z., von Wolff, M.
(2008). GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy. Hum Reprod Update
0: dmn022v1-10
[Abstract][Full Text]
Beck-Fruchter, R., Weiss, A., Shalev, E.
(2008). GnRH agonist therapy as ovarian protectants in female patients undergoing chemotherapy: a review of the clinical data. Hum Reprod Update
0: dmn041v1-9
[Abstract][Full Text]
DiLuigi, A., Weitzman, V. N., Pace, M. C., Siano, L. J., Maier, D., Mehlmann, L. M.
(2008). Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway. Biol. Reprod.
78: 667-672
[Abstract][Full Text]
Moore, H. C. F.
(2008). Ovarian Failure after Chemotherapy for Breast Cancer and the Role of Gonadotropin-releasing Hormone Analogs in Protection of Ovarian Function. Am Soc Clin Oncol Ed Book
2008: 39-42
[Abstract][Full Text]
Demeestere, I., Simon, P., Emiliani, S., Delbaere, A., Englert, Y.
(2007). Fertility Preservation: Successful Transplantation of Cryopreserved Ovarian Tissue in a Young Patient Previously Treated for Hodgkin's Disease. The Oncologist
12: 1437-1442
[Abstract][Full Text]
Blumenfeld, Z.
(2007). How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries. The Oncologist
12: 1044-1054
[Abstract][Full Text]
Blumenfeld, Z., Arush, M. B., Zuckerman, T.
(2007). Spontaneous pregnancy and normal delivery after repeated autologous bone marrow transplantation and GnRH agonist treatment. Hum Reprod
22: 2346-2346
[Full Text]
Jones, K.P., Walker, L.C., Anderson, D., Lacreuse, A., Robson, S.L., Hawkes, K.
(2007). Depletion of Ovarian Follicles with Age in Chimpanzees: Similarities to Humans. Biol. Reprod.
77: 247-251
[Abstract][Full Text]
Yeh, J., Kim, B.
(2007). Increasing Blunting of Inhibin Responses to Dynamic Ovarian Challenge Is Associated With Reproductive Aging in the Rat. Reproductive Sciences
14: 10-19
[Abstract]
Donnez, J., Martinez-Madrid, B., Jadoul, P., Van Langendonckt, A., Demylle, D., Dolmans, M.-M.
(2006). Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update
12: 519-535
[Abstract][Full Text]
Goodwin, P. J., Oktay, K. H., Lobo, R. A.
(2005). Options for preservation of fertility in women.. NEJM
353: 1418-1420
[Full Text]