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Previous Volume 353:82-84 July 7, 2005 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Endogenously released nitric oxide is widely recognized to play a key role in multiple vertebrate organ systems, and its deficiency disrupts pulmonary parenchymal and vascular development. These observations have suggested that exogenously inhaled nitric oxide might protect the respiratory and the central nervous systems during a critical phase of development and thus improve outcomes in preterm infants.

In this issue of the Journal, Mestan et al.¹ and Van Meurs et al.² assess the utility of inhaled nitric oxide in preterm neonates with respiratory failure, with contrasting results. Mestan and colleagues report improved cognitive neurodevelopmental outcome in two-year-olds who had been . . . [Full Text of this Article]

Source Information

From the Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland.

Related Letters:

Inhaled Nitric Oxide
Dani C., Bertini G., Rubaltelli F. F., Hasan S. U., Lasser E. C., Van Meurs K., Stevenson D., Schreiber M. D., Marks J. D., Mestan K. K.L., Martin R. J., Walsh M. C.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:1626-1628, Oct 13, 2005. Correspondence

This article has been cited by other articles:

• Barrington, K. J., Finer, N. N. (2007). Inhaled Nitric Oxide for Preterm Infants: A Systematic Review. Pediatrics 120: 1088-1099 [Abstract] [Full Text]  
• Ballard, R. A., Truog, W. E., Cnaan, A., Martin, R. J., Ballard, P. L., Merrill, J. D., Walsh, M. C., Durand, D. J., Mayock, D. E., Eichenwald, E. C., Null, D. R., Hudak, M. L., Puri, A. R., Golombek, S. G., Courtney, S. E., Stewart, D. L., Welty, S. E., Phibbs, R. H., Hibbs, A. M., Luan, X., Wadlinger, S. R., Asselin, J. M., Coburn, C. E., the NO CLD Study Group, (2006). Inhaled nitric oxide in preterm infants undergoing mechanical ventilation.. NEJM 355: 343-353 [Abstract] [Full Text]  
• (2005). Should We Say NO to Preemies?. JWatch Neurology 2005: 4-4 [Full Text]  
• Dani, C., Bertini, G., Rubaltelli, F. F., Hasan, S. U., Lasser, E. C., Van Meurs, K., Stevenson, D., Schreiber, M. D., Marks, J. D., Mestan, K. K.L., Martin, R. J., Walsh, M. C. (2005). Inhaled nitric oxide.. NEJM 353: 1626-1628 [Full Text]