Osteonecrosis of the Jaw and Bisphosphonates

doi:10.1056/NEJM200507073530120

A correction has been published: N Engl J Med 2005;353(25):2728.

Volume 353:99-102		July 7, 2005		Number 1

Osteonecrosis of the Jaw and Bisphosphonates

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To the Editor: Cases of osteonecrosis of the jaw in connectionwith the use of bisphosphonates were reported in 2003.¹^,² In2004, the International Myeloma Foundation conducted a Web-basedsurvey to assess the risk factors for osteonecrosis of the jaw.Of 1203 respondents, 904 had myeloma and 299 breast cancer.Both osteonecrosis and suspicious findings, including bone erosionsand spurs plus exposed bone, were assessed. Sixty-two patientswith myeloma had osteonecrosis of the jaw and 54 had suspiciousfindings; 13 patients with breast cancer had osteonecrosis and23 had suspicious findings — a total of 152 patients witheither osteonecrosis . . . [Full Text of this Article]

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