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Editorial
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Volume 353:1162-1164 September 15, 2005 Number 11
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Prophylactic Thyroidectomy in MEN-2A — A Stitch in Time?
Francis D. Moore, M.D., and Robert G. Dluhy, M.D.

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by Skinner, M. A.
-PubMed Citation
Multiple endocrine neoplasia (MEN) type 2A (MEN-2A) and type 2B (MEN-2B) illustrate the remarkable pace of knowledge that has been acquired about a group of heritable disorders. In 1961, Sipple made astute clinical observations associating bilateral pheochromocytomas with carcinoma of the thyroid gland.1 Others subsequently identified the thyroid neoplasm involved as medullary thyroid carcinoma, which is derived from calcitonin-producing parafollicular, or C, cells. Serum calcitonin concentrations were found to be elevated in patients with medullary thyroid carcinoma, and these increased levels served as a useful tumor marker. Clinical syndromes associated with hereditary medullary thyroid carcinoma include MEN-2A, or Sipple's syndrome . . . [Full Text of this Article]



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