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Clinical Implications of Basic Research
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Volume 353:1177-1179 September 15, 2005 Number 11
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Anchors Away — Of Plaques and Pathology in Prion Disease
Glenn Telling, Ph.D.

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The accumulation of conformationally altered cellular proteins is a common feature underlying the pathogenesis of neurodegenerative conditions such as Alzheimer's disease and the prion diseases. However, the proteins that cause prion diseases are uniquely infectious. The neuropathological profiles of Alzheimer's disease and certain prion diseases such as variant Creutzfeldt–Jakob disease (the human manifestation of bovine spongiform encephalopathy) involve the aggregation of the etiologic protein into amyloid plaques, but the relationship between plaque formation and disease has been the focus of debate. A recent study by Chesebro and colleagues1 weighs in on one side.

Studies of transgenic mice and cell-free systems . . . [Full Text of this Article]


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From the Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington.



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