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1:8) represents a potentially useful advance in syphilis control. In a randomized trial reported in this issue of the Journal, Riedner et al.1 achieved cure rates of 97.7 percent with 2 g of azithromycin given orally and 95.0 percent with 2.4 MU of penicillin G benzathine given intramuscularly. Positive or negative status with respect to human immunodeficiency virus (HIV) infection did not influence the results of treatment. Titers on rapid plasma reagin tests fell
Source Information
From the Department of Medicine and the Center for AIDS and Sexually Transmitted Diseases, University of Washington, Seattle.
Related Letters:
Azithromycin versus Penicillin for Early Syphilis
Ballard R. C., Berman S. M., Fenton K. A., Savaris R. F., Abeche A. M., Klausner J. D., Kohn R. P., Kent C. K., Riedner G., Grosskurth H., Hayes R., Holmes K. K.
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N Engl J Med 2006;
354:203-205, Jan 12, 2006.
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