EDITOR'S NOTE:Due to broad interest in the avian flu, this article is free to access, and it has been translated into multiple languages to assist clinicians around the world:
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An unprecedented epizootic avian influenza A (H5N1) virus thatis highly pathogenic has crossed the species barrier in Asiato cause many human fatalities and poses an increasing pandemicthreat. This summary describes the features of human infectionwith influenza A (H5N1) and reviews recommendations for preventionand clinical management presented in part at the recent WorldHealth Organization (WHO) Meeting . . . [Full Text of this Article]
Incidence
Transmission
Animal to Human
Human to Human
Environment to Human
Clinical Features
Incubation
Initial Symptoms
Clinical Course
Mortality
Laboratory Findings
Virologic Diagnosis
Management
Pathogenesis
Characterization of Virus
Patterns of Viral Replication
Host Immune Responses
Pathological Findings
Case Detection and Management
Hospitalization
Antiviral Agents
Immunomodulators
Prevention
Immunization
Hospital-Infection Control
Household and Close Contacts
Conclusions
Source Information
The writing committee consisted of the following: John H. Beigel, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.; Jeremy Farrar, D.Phil., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Aye Maung Han, M.B., B.S., Department of Child Health, Institute of Medicine, Yangon, Myanmar; Frederick G. Hayden, M.D. (rapporteur), University of Virginia, Charlottesville; Randy Hyer, M.D., World Health Organization, Geneva; Menno D. de Jong, M.D., Ph.D., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Sorasak Lochindarat, M.D., Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Nguyen Thi Kim Tien, M.D., Ph.D., Pasteur Institute, Ho Chi Minh City, Vietnam; Nguyen Tran Hien, M.D., Ph.D., National Institute of Hygiene and Epidemiology, Hanoi; Tran Tinh Hien, M.D., Ph.D., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Angus Nicoll, M.Sc., Health Protection Agency, London; Sok Touch, M.D., Ministry of Health, Phnom Penh, Cambodia; and Kwok-Yung Yuen, M.D., University of Hong Kong, Hong Kong SAR, China.
Address reprint requests to Dr. Hayden at the Department of Internal Medicine, P.O. Box 800473, University of Virginia Health Sciences Center, Charlottesville, VA 22908, or at fgh@virginia.edu.
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