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A correction has been published: N Engl J Med 2006;354(8):884.

Review Article
Current Concepts
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Volume 353:1374-1385 September 29, 2005 Number 13
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Avian Influenza A (H5N1) Infection in Humans
The Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5

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EDITOR'S NOTE: Due to broad interest in the avian flu, this article is free to access, and it has been translated into multiple languages to assist clinicians around the world:
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Italiano  

An unprecedented epizootic avian influenza A (H5N1) virus that is highly pathogenic has crossed the species barrier in Asia to cause many human fatalities and poses an increasing pandemic threat. This summary describes the features of human infection with influenza A (H5N1) and reviews recommendations for prevention and clinical management presented in part at the recent World Health Organization (WHO) Meeting . . . [Full Text of this Article]

Incidence

Transmission

Animal to Human

Human to Human

Environment to Human

Clinical Features

Incubation

Initial Symptoms

Clinical Course

Mortality

Laboratory Findings

Virologic Diagnosis

Management

Pathogenesis

Characterization of Virus

Patterns of Viral Replication

Host Immune Responses

Pathological Findings

Case Detection and Management

Hospitalization

Antiviral Agents

Immunomodulators

Prevention

Immunization

Hospital-Infection Control

Household and Close Contacts

Conclusions


Source Information

The writing committee consisted of the following: John H. Beigel, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.; Jeremy Farrar, D.Phil., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Aye Maung Han, M.B., B.S., Department of Child Health, Institute of Medicine, Yangon, Myanmar; Frederick G. Hayden, M.D. (rapporteur), University of Virginia, Charlottesville; Randy Hyer, M.D., World Health Organization, Geneva; Menno D. de Jong, M.D., Ph.D., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Sorasak Lochindarat, M.D., Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Nguyen Thi Kim Tien, M.D., Ph.D., Pasteur Institute, Ho Chi Minh City, Vietnam; Nguyen Tran Hien, M.D., Ph.D., National Institute of Hygiene and Epidemiology, Hanoi; Tran Tinh Hien, M.D., Ph.D., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Angus Nicoll, M.Sc., Health Protection Agency, London; Sok Touch, M.D., Ministry of Health, Phnom Penh, Cambodia; and Kwok-Yung Yuen, M.D., University of Hong Kong, Hong Kong SAR, China.

Address reprint requests to Dr. Hayden at the Department of Internal Medicine, P.O. Box 800473, University of Virginia Health Sciences Center, Charlottesville, VA 22908, or at fgh@virginia.edu.


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