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Previous Volume 353:1400-1402 September 29, 2005 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although aortic regurgitation imposes a volume load on the left ventricle, it became clear more than two decades ago that the resulting large stroke volume and wide pulse pressure also lead to systolic hypertension and concomitant left ventricular pressure overload.^1,2 In fact, afterload is much higher in aortic regurgitation than in mitral regurgitation and may be as high as that in the more typically recognized pressure overload of aortic stenosis.³ The excess afterload in aortic regurgitation, in turn, forms the basis for the idea that afterload-reducing agents, such as vasodilators, might be beneficial in the medical treatment of this disease.

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Source Information

From the Michael E. DeBakey Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine — both in Houston.

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• Takagi, H., Umemoto, T., Krasuski, R. A., Griffin, B. P., Afshinnia, F., Rahimtoola, S. H., Evangelista, A., Tornos, P., Permanyer-Miralda, G. (2006). Vasodilators in Aortic Regurgitation. NEJM 354: 300-303 [Full Text]  
• (2005). Vasodilators Tested in Asymptomatic Aortic Regurgitation. Journal Watch Cardiology 2005: 1-1 [Full Text]  
• (2005). Vasodilator Therapy Disappointing in Chronic Aortic Regurgitation. JWatch General 2005: 2-2 [Full Text]