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Volume 353:1527-1529 October 6, 2005 Number 14
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Torcetrapib and Atorvastatin

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 by Avorn, J.
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To the Editor: Avorn's proposal in his Perspective article (June 23 issue)1 that the combination of torcetrapib and atorvastatin is market-driven, undermining its usefulness, is baseless. The program does not extend the patent on atorvastatin. Its basic aim is to provide efficiently the greatest medical benefit to the most patients while maintaining the greatest likelihood of success.

Mandatory control of low-density lipoprotein (LDL) cholesterol is a foundation of treatment for patients who are at increased risk for heart disease, including those with isolated low levels of high-density lipoprotein (HDL) cholesterol.2 Torcetrapib alone at the dose used in phase 3 studies . . . [Full Text of this Article]




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