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Volume 353:1632-1633 October 13, 2005 Number 15
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{gamma}-Hydroxybutyric Acid

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 by Snead, O. C.
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To the Editor: In the review article by Snead and Gibson (June 30 issue)1 on the recreational use of {gamma}-hydroxybutyric acid (GHB), it is stressed that GHB is undetectable in current toxicologic screens and that specific analyses may not be rapidly obtainable.

This should not be the case. Most biochemical genetics laboratories are familiar with the detection of GHB. The level of this compound is markedly increased in the urine of persons affected by the neurometabolic disorder succinic semialdehyde dehydrogenase deficiency and will be detected by urinary organic acid analysis. In fact, the use of GHB for the sedation of . . . [Full Text of this Article]


Related Letters:

{gamma}-Hydroxybutyric Acid in Hair
Mion G., Tourtier J.-P., Diraison Y.
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N Engl J Med 2006; 354:96-97, Jan 5, 2006. Correspondence

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