The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Perspective
PreviousPrevious
Volume 353:1646-1647 October 20, 2005 Number 16
NextNext

A Tetraploid Twist on the Embryonic Stem Cell
Elizabeth G. Phimister, Ph.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-PubMed Citation
The production of human embryonic stem cells by somatic-cell nuclear transfer depends on a profound but obscure event that takes place when the nucleus of a "donor" somatic cell is injected into an enucleated ovum (see diagram). Somehow, the cytoplasm of the oocyte reprograms the chromosomes of the somatic cell's nucleus so that the newly formed cell becomes pluripotent. The cell develops into a blastocyst, from which embryonic stem cells can be derived that carry a set of chromosomes identical to that of the donor. The "tailored" embryonic stem cells thus derived have fueled hope for new treatments for . . . [Full Text of this Article]


Source Information

Dr. Phimister is a deputy editor of the Journal.



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.