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Volume 353:1746-1747 October 20, 2005 Number 16
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A Relapsing Inflammatory Syndrome and HHV-8

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by Dagna, L.
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To the Editor: The case of human herpesvirus 8 (HHV-8) reported by Dagna et al. (July 14 issue)1 is considered to be distinct from HHV-8–associated multicentric Castleman's disease owing to the absence of typical histologic findings and elevated plasma levels of interleukin-6. The histopathology of HHV-8–associated multicentric Castleman's disease is variable, as compared with the classic descriptions of HHV-8–negative Castleman's disease2,3,4 and would encompass the changes described in the report, especially in the context of cytotoxic treatment before biopsy. In HHV-8–associated multicentric Castleman's disease, the HHV-8–infected B-lineage cells can be seen either within the B-cell follicles or in the interstitium . . . [Full Text of this Article]



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