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Previous Volume 353:1768-1771 October 27, 2005 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Recent discoveries related to microRNAs, RNA interference, small interfering RNAs (siRNAs), and small modulatory RNAs have revealed a new class of mechanisms of gene regulation that are mediated by small, noncoding RNAs. Among these small RNAs are the microRNAs. These are thought to control gene expression at the post-transcriptional level by degrading or repressing target messenger RNAs (mRNAs). Surprisingly simple and elegant, microRNA-mediated gene regulation is guided by the base-pairing rules of Watson and Crick.

MicroRNAs are individually encoded by their own set of genes and are an integral component of the genetic program. Some are located in noncoding regions . . . [Full Text of this Article]

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Dr. Chen is an assistant professor in the Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer/Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, Calif.

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