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Previous Volume 353:1965-1968 November 3, 2005 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although our understanding of the pathogenesis of the chief forms of inflammatory bowel disease, Crohn's disease, and ulcerative colitis remains incomplete, progress is being made in identifying essential components.¹ The presence of large numbers of varied leukocytes within affected tissue where they are normally sparse makes it axiomatic that active disease is dependent on the recruitment of these cell populations. Recruitment is now known to proceed through a stereotypical series of steps that depend on selective adhesion molecules (SAMs). These include cell-surface integrins, heterodimers formed by various combinations of and subunits. Integrins with an ₄ chain appear to play an especially . . . [Full Text of this Article]

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From Massachusetts General Hospital, Boston.

Related Letters:

Selective Adhesion-Molecule Therapy and Inflammatory Bowel Disease
Chaudhuri A., Podolsky D. K.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:644-645, Feb 9, 2006. Correspondence

This article has been cited by other articles:

• Chaudhuri, A., Podolsky, D. K. (2006). Selective Adhesion-Molecule Therapy and Inflammatory Bowel Disease. NEJM 354: 644-645 [Full Text]