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Case Records of the Massachusetts General Hospital
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Volume 353:189-198 July 14, 2005 Number 2
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Case 21-2005 — A Four-Week-Old Male Infant with Jaundice and Thrombocytopenia
Nancy C. Andrews, M.D., Ph.D., Sudha Anupindi, M.D., and Kamran Badizadegan, M.D.

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Presentation of Case

A four-week-old male infant was admitted to this hospital because of jaundice, hyperbilirubinemia, thrombocytopenia, and abdominal distention.

The patient was born at term at another hospital by spontaneous vaginal delivery to a 37-year-old woman (gravida 2, para 2) after an uncomplicated pregnancy. Prenatal screening revealed that the mother had type A Rh-positive blood. Tests for hepatitis B surface antigen and group B streptococcus were negative. The mother was immune to rubella, and a rapid plasma reagin test was nonreactive. Before the delivery, decreased variability was noted on the fetal-heart tracing. At delivery, the infant was limp, cyanotic, apneic, and without . . . [Full Text of this Article]

Differential Diagnosis

Metabolic Causes of Neonatal Hemochromatosis

Maternal Conditions Associated with Neonatal Hemochromatosis

Primary Abnormalities of Iron Homeostasis

Clinical Diagnosis

Dr. Nancy Andrews's Diagnosis

Pathological Discussion

Anatomical Diagnosis


Source Information

From the Department of Pediatrics, Children's Hospital (N.C.A.); the Departments of Radiology (S.A.) and Pathology (K.B.), Massachusetts General Hospital; and the Departments of Pediatrics (N.C.A.), Radiology (S.A.), and Pathology (K.B.), Harvard Medical School — all in Boston.


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