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Previous Volume 353:207-208 July 14, 2005 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Patients with lung cancer who respond to gefitinib have been reported to have somatic mutations consisting of deletions in exon 19 and the L858R mutation in exon 21 of the epidermal growth factor receptor (EGFR) gene.¹ In addition, a second mutation (T790M) in exon 20 is also associated with acquired resistance to gefitinib in initially gefitinib-sensitive patients.^2,3 We describe a patient with gefitinib-resistant lung adenocarcinoma harboring both T790M and L858R at diagnosis.

A 55-year-old woman who had never smoked presented with blurred vision and slurred speech. Magnetic resonance imaging of the brain disclosed a rim-enhanced . . . [Full Text of this Article]

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