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Volume 353:2191 November 17, 2005 Number 20
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Bone Marrow Micrometastases in Breast Cancer

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by Braun, S.
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To the Editor: Braun and colleagues (Aug. 25 issue)1 report that the presence of micrometastases in the bone marrow of patients with breast cancer is an independent predictor of a poor prognosis. The authors cite the fact that this finding held true for patients with early-stage (pT1N0) disease as a potential rationale for further substratification with respect to the use of systemic adjuvant therapy. It is notable that 1036 patients in this study had pT1N0 disease and did not receive systemic adjuvant therapy. With regard to counseling patients with pT1N0 disease, it would be helpful to know the precise outcomes . . . [Full Text of this Article]



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