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Volume 353:2209-2211 November 24, 2005 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The completion of the genetic sequencing of the 1918 influenza A virus by Taubenberger et al.¹ and the subsequent recovery of the virus by Tumpey et al.² using reverse genetic techniques are spectacular achievements of contemporary molecular biology and provide important insights into the origin of pandemic influenza. The three pandemic viruses that emerged in the 20th century — the 1918 ("Spanish influenza") H1N1 virus, the 1957 ("Asian influenza") H2N2 virus, and the 1968 ("Hong Kong influenza") H3N2 virus — all spread rapidly around the world, but only the 1918 virus was associated with mortality measured in the thousands per . . . [Full Text of this Article]

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Dr. Belshe is a professor of medicine, pediatrics, and molecular microbiology in the Division of Infectious Diseases and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis.

An interview with Dr. Belshe can be heard at www.nejm.org.

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