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Case Records of the Massachusetts General Hospital
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Volume 353:2271-2280 November 24, 2005 Number 21
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Case 36-2005 — A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status
Bradford C. Dickerson, M.D., David Holtzman, M.D., Ph.D., P. Ellen Grant, M.D., and Di Tian, M.D., Ph.D.

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Presentation of Case

Dr. Ronan Walsh (Department of Neurology, Brigham and Women's Hospital): A 61-year-old left-handed woman was admitted to the neurology service of this hospital because of a seizure and altered mental status.

On the morning of admission, her husband awoke at 4 a.m. to find her thrashing in bed, with rhythmic movements of all four extremities, for two to five minutes. She subsequently appeared groggy but alert, with a facial droop, garbled speech, and an inability to follow verbal commands. Emergency-medical-services personnel were called and she was brought to the emergency department of this hospital and admitted to the neurology service.

. . . [Full Text of this Article]

Differential Diagnosis

Mitochondrial Encephalomyopathies

Clinical Diagnosis

Dr. Bradford C. Dickerson's Diagnosis

Pathological Discussion

Discussion of Management

Anatomical Diagnosis


Source Information

From the Departments of Neurology (B.C.D., D.H.) and Pediatrics (D.H.), the Division of Pediatric Radiology, Department of Radiology (P.E.G.), and the Department of Pathology (D.T.), Massachusetts General Hospital; the Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital (B.C.D.); and the Departments of Neurology (B.C.D., D.H.), Pediatrics (D.H.), Radiology (P.E.G.), and Pathology (D.T.), Harvard Medical School — all in Boston.


Related Letters:

Case 36-2005: A Woman with Seizure, Disturbed Gait, and Altered Mental Status
Geberhiwot T., Chakrapani A., Hendriksz C., Holtzman D., Dickerson B. C.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:1096-1097, Mar 9, 2006. Correspondence

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