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Editorial
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Volume 353:2288-2290 November 24, 2005 Number 21
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Beta-Blockers to Prevent Esophageal Varices — An Unfulfilled Promise
Sandeep Mukherjee, M.D., M.P.H., and Michael F. Sorrell, M.D.

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 by Groszmann, R. J.
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Variceal bleeding is the most feared complication of portal hypertension in patients with cirrhosis and is a major cause of death. Treatments frequently include endoscopic banding or sclerotherapy of esophageal varices in parallel with splanchnic vasoconstrictors and intensive medical care.1 Alternative interventions, such as decompressive surgical shunts, transjugular intrahepatic systemic shunts, and liver transplantation, are needed in patients with esophageal variceal bleeding refractory to endoscopic intervention or patients with bleeding from gastric or ectopic varices. However, the choice of therapy is based on the presence or absence of decompensated liver disease and is often influenced by local expertise. For example, . . . [Full Text of this Article]


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From the University of Nebraska Medical Center, Omaha.




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