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Clinical Implications of Basic Research
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Volume 353:2508-2509 December 8, 2005 Number 23
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Understanding Heme Transport
Nancy C. Andrews, M.D., Ph.D.

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Iron, the most abundant transition metal in the body, is an essential cofactor for proteins involved in oxygen transport, electron exchange, and the control of toxic free radicals. It is extracted from the diet in either of two forms — inorganic iron (primarily from nonanimal sources) or heme (mostly from hemoglobin and myoglobin). Over the past decade, the mechanism for the absorption of nonheme iron has been worked out in some detail,1 but specifics of the absorption of heme have remained uncertain. In a recent article, Shayeghi and colleagues reported the discovery of heme carrier protein 1 (HCP1), the first . . . [Full Text of this Article]


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From Children's Hospital and Harvard Medical School — both in Boston.


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