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Volume 353:2621-2623 December 15, 2005 Number 24
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Sudden Reversible Osmotic Lens Damage ("Sugar Cracks") after Initiation of Metformin

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To the Editor: We observed a unique type of ocular lens damage in a 62-year-old man with no history of ophthalmologic disease. He had a history of heart failure requiring five-vessel cardiac bypass surgery. He had polydipsia and polyuria, which became markedly aggravated after an overseas trip; on the patient's return, his primary care physician diagnosed diabetes mellitus (serum glucose level, 21.8 mmol per liter [393 mg per deciliter]; glycosylated hemoglobin level, 17.5 percent). Metformin (at a dose of 750 mg twice daily) reduced the serum glucose level to 14.6 mmol per liter (263 mg per deciliter) within four days . . . [Full Text of this Article]




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