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Previous Volume 353:2625 December 15, 2005 Number 24 Next

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By Adam H. Balen, Gerard S. Conway, Roy Homburg, and Richard S. Legro. 211 pp., plus index, illustrated. Abingdon, England, Taylor & Francis, 2005. $149.95. ISBN 1-84214-211-9.

Seventy years ago, two North American gynecologists, Stein and Leventhal, published the first clear clinical description of what is now called the polycystic ovary syndrome in infertile women who were usually obese and hirsute, had irregular menstrual cycles, and had large ovaries with multiple peripheral cysts. Removal of part of the ovary by wedge resection led to a restoration of fertility in the majority of women with this disorder. The presentation of the syndrome with infertility has now been augmented by the discovery of insulin resistance, hyperlipidemia, and features of the metabolic syndrome in many patients. These findings have led . . . [Full Text of this Article]

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